cellular response to ionizing radiation: a microrna story

نویسندگان

mohammad halimi department of biology, faculty of sciences, university of guilan, rasht, iran.سازمان اصلی تایید شده: دانشگاه گیلان (guilan university)

mohsen asghari department of biology, faculty of sciences, university of guilan, rasht, iran.سازمان اصلی تایید شده: دانشگاه گیلان (guilan university)

reyhaneh sariri department of biology, faculty of sciences, university of guilan, rasht, iran.سازمان اصلی تایید شده: دانشگاه گیلان (guilan university)

dariush moslemi department of radiation oncology, babol university of medical sciences, babol, iran.سازمان اصلی تایید شده: دانشگاه علوم پزشکی بابل (babol university of medical sciences)

چکیده

micrornas (mirnas) represent a class of small non-coding rna molecules that regulate gene expression at the post-transcriptional level. they play a crucial role in diverse cellular pathways. ionizing radiation (ir) is one of the most important treatment protocols for patients that suffer from cancer and affects directly or indirectly cellular integration. recently it has been discovered that microrna-mediated gene regulation interferes with radio-related pathways in ionizing radiation. here, we review the recent discoveries about mirnas in cellular response to ir. thoroughly understanding the mechanism of mirnas in radiation response, it will be possible to design new strategies for improving radiotherapy efficiency and ultimately cancer treatment.

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عنوان ژورنال:
international journal of molecular and cellular medicine

جلد ۱، شماره ۴، صفحات ۱۷۸-۱۸۴

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